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How Coffee Enemas Are Thought to Work Proponents of coffee enemas claim that the caffeine and other compounds in coffee can stimulate bile flow, promote detoxification, and potentially increase glutathione levels

With both oral and injectable options, low monthly costs, and month-to-month flexibility, its an accessible entry point for GLP-1 therapy

With an increased rate of angiogenesis (blood vessel production), upregulated actin and cell movement, there is an elevated expression of crucial repair factors such as VEGFR2 and EGR-1

doi: 10.3389/fphar.2025.1551843 Received 26 December 2024 Accepted 09 June 2025 Published 02 July 2025 Volume 16 - 2025 Edited by Ting Shen, Yangzhou University, China Reviewed by Shuo Yuan, University of Virginia, United States Yan Hu, Second Affiliated Hospital of Dalian Medical University, China Updates Copyright 2025 Mao, Huang, Li, Sun, Zhang, Cheng, Zeng, Lei, Wang and Yao