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Drinking a good amount of water about 20-30 minutes before a meal has been shown to reduce calorie intake in some studies

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Consider oxidative stress markers (8-OHdG, MDA), direct glutathione measurement (GSH:GSSG ratio), mitochondrial function indicators, inflammatory markers (hs-CRP, IL-6), and genetic assessment of detoxification capacity

Pfeffer MA, Claggett B, Diaz R et al (2015) Lixisenatide in patients with type 2 diabetes and acute coronary syndrome