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Brand Name Medication Costs (Without Insurance) If you walk into a pharmacy without insurance and ask for brand-name GLP-1 weight loss medications, heres what youll pay: Wegovy (semaglutide for weight loss): $1,300-$1,500/month Zepbound (tirzepatide for weight loss): $1,000-$1,200/month Ozempic (semaglutide for diabetes, often used off-label): $900-$1,000/month Mounjaro (tirzepatide for diabetes, often used off-label): $900-$1,100/month At these prices, a year of treatment costs $10,000-$18,000