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This happens even at maximum doses
While their roles in glycemic control and weight reduction are well established, the broader clinical impact involves cardiovascular protection, reduced heart failure hospitalization risk, renal support and hepatic benefits for patients with existing or emerging cardiometabolic disease
Patients with pre-existing inflammatory bowel disease (IBD), including ulcerative colitis or Crohn's disease, should discuss their condition with their healthcare provider before starting semaglutide
The role of GLP-1 in neuronal activity and neurodegeneration
Currently, several co- and tri-agonists targeting the GLP-1R and the GIPR in combination with the GCGR are under investigation for metabolic conditions including obesity
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