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Recent research data has shown that the expression of lipid metabolism genes adiponectin (APN), Adipo R, AMPK, PPAR mRNA and protein is significantly increased after 48 hours of treatment with different concentrations of GLP-1 compared with the model group of adipose hepatocytes [108]

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Given that the kidney-protective effects of SGLT2 inhibitors are independent of glucose lowering [51], DAPA-CKD and EMPA-KIDNEY have included participants both with and without diabetes mellitus (Table 1, Fig

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