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Monotherapy reached near 10.8 percent at the top dose by week 26 against roughly 3 percent on placebo, with the usual mild appetite-agent side effects
Its mechanisms are well characterized
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SARS-CoV-2 spike glycoprotein binds TLR4 and activates TLR4 signaling increasing cell surface expression of ACE2 facilitating entry (Aboudounya and Heads, 2021)
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