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GIP is the main incretin hormone in healthy people, causative of most the incretin effects but the insulin response after GIP secretion in T2DM is reduced [12]
Rapid weight loss without resistance training can lead to muscle loss
Backed-up stool adds physical weight
Initial weight changes may appear within 46 weeks, though meaningful weight reduction (typically 5% or more of initial body weight) generally occurs over 36 months
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