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Ammonia readily crosses the blood-brain barrier and is thought to inhibit glutamate uptake, thereby increasing extracellular glutamate concentrations in the brain and resulting in activation of NMDA receptors

P5 is more effective at controlling chronic hyperglycaemia To determine whether chronic treatment with the GLP-1R G-protein-biased agonist can improve hyperglycaemia, ob/ob mice were treated daily with 10 g kg 1 of P5 or Ex4 for 3 weeks

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It has been observed to reduce HbA1c levels, a key marker of long-term blood glucose control