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Eight in vivo and two in vitro experiments have been identified that demonstrate the effect of these ITC on diabetes-related cognitive decline

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Stress is another known trigger that may push susceptible individuals into an autoimmune state

In future trials it will be important to keep track of comorbidities for clinical trial design, either for the purpose of post hoc subgroup analysis or a priori subgroup recruitment, since the neuroathophysiological mechanisms in IC/ BPS patients with different co-morbidities are likely to be different

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