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For weight loss patients, the emphasis shifts toward side effect management, expectations around weight trajectories, and the importance of adherence

Over the years, this class of drugs has been shown to help many individuals achieve meaningful weight loss when paired with a reduced-calorie diet and increased physical activity

Consumers should be skeptical of any over-the-counter product marketed as a GLP-1 supplement that suggests it can act like a prescription drug, replace a GLP-1 medication or treat a disease such as obesity, says Jeff Ventura, a spokesperson for the Council for Responsible Nutrition, which represents the dietary supplement industry

These drugs mimic a hormone called glucagon-like peptide-1, which helps regulate blood sugar and appetite

A leading theory postulates that excitatoryinhibitory (that is, glutamateGABA) imbalance in the cortex ultimately leads to dysfunction of the dopaminergic system