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Sonali Thosani, M.D
Understanding the full spectrum helps patients and clinicians identify and describe their symptoms more precisely
Tirzepatide and retatrutide (single molecule): A single engineered molecule that hits multiple receptors simplifies the formulation to one compound with one pharmacokinetic profile, and allows the balance of receptor activation to be tuned at the molecular-design level
In one published case, an active, lean-adjacent man lost about one-third of his total weight as muscle on 2.5 mg and recovered it after adding resistance training and increasing protein. This is a cautionary case, not an incidence estimate
doi: 10.3389/fphys.2020.582449 Received 12 July 2020 Accepted 26 August 2020 Published 26 October 2020 Volume 11 - 2020 Edited by Mohsin Khan, Temple University, United States Reviewed by Song-Gyu Ra, Tokushima University, Japan
