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It aims to dissect the molecular pathways, evaluate the animal model data, and critically assess the state of human research to equip clinicians with a balanced and actionable perspective

doi: 10.1016/j.bbrc.2017.06.190 99 BerthelootDLatzEFranklinBS

AyalaAMunozMFArguellesS.Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal

Under normal conditions, glutathione levels are tightly regulated to ensure both adequate antioxidant capacity and controlled metabolic flux through its biosynthetic pathway

The mechanisms likely involve a combination of its anti-inflammatory properties and its core angiogenic action, which improves blood flow to the injured site and supports the survival of salvageable neurons