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It is widely hypothesized that dysfunction in various components of the glutamate-GABA system contributes to neurodevelopmental and neurodegenerative disorders ( 1,2 Regional and circuit-specific dysfunction resulting in an excitatory-inhibitory imbalance is believed to contribute to these disorders based on the location of the dysfunction and the temporal onset of the imbalance

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Also associated with CGD is a high prevalence of invasive fungal infections affecting 20%40% of CGD patients

Phase II attaches these intermediates to a carrier molecule for excretion

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