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These findings indicate that sustainable lifestyle approaches, such as diet and exercise, could help support the management of post-cessation weight regain, thereby helping to manage SO risk in older adults (Fig

Sorbitol, unlike glucose, cannot pass efficiently through cell membranes and therefore remains trapped inside the cells, increasing osmolality, resulting in swollen cells due to water retention

B5 (pantothenic acid) is a precursor to coenzyme A, central to fat metabolism

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Clinicians managing patients on testosterone who wish to explore retatrutide should: Consult the relevant clinical trial protocols if the patient is enrolled in a study Seek specialist endocrinology input before initiating any off-label or investigational combination Document clinical rationale clearly , obtain informed consent, and follow GMC Good Practice in Prescribing and Managing Medicines and Devices guidance when considering unlicensed or investigational treatments Until formal guidance is available, clinical decision-making should be guided by individual patient riskbenefit assessment, informed consent, and regular monitoring