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Glutathione deficiency states include, but are not limited to, HIV/AIDS, chemical and infectious hepatitis, myalgic encephalomyelitis chronic fatigue syndrome, prostate and other cancers, cataracts, Alzheimer's disease, Parkinson's disease, chronic obstructive pulmonary disease, asthma, radiation poisoning, malnutritive states, arduous physical stress, and aging, and has been associated with suboptimal immune response
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These may include the sensation of sand or gravel in the eye or the need to drink liquids frequently to contrast oral dryness ( Systemic manifestations of SS include cryoglobulinemic purpura, non-erosive symmetrical arthritis, interstitial lung disease, Raynaud's phenomenon, pericarditis, autoimmune hepatitis and primary biliary cirrhosis, polyneuropathy, thyroiditis, B cell lymphoma, autoimmune haemolytic anemia, and eventually renal disease, ranging from glomerulonephritis to tubulointerstitial nephritis ( Renal involvement has long been known to be multifaceted and possibly underestimated in SS
