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In the physiological context, our convergent data from intra-OB Ex9, IPGTT and ex vivo OB GLP-1 release experiments indicate local production of GLP-1 in the OB, presumably independently of peripherally derived GLP-1

These medications flood your body with amplified versions of these natural signals

Semaglutide is an FDA-approved GLP-1 medication for individuals with obesity and type 2 diabetes mellitus when combined with a healthy diet and exercise

For most patients, side effects largely resolve by week three to four as your body adapts to the medication

It also means that GLP-1s can validate and reinforce disordered thoughts and behaviors rather than raise the red flags that may otherwise prompt intervention