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These results suggest that inflammatory cytokines may be key players in the progression of Genta-induced proximal tubule dysfunction and nephrotoxicity

PMID: 2555512 PMC1572913 Pigmentation Pathway (MC1R, Preclinical) Eumelanin upregulation via cAMP / MITF / tyrosinase axis MC1R activation by melanocortin agonists is reported to raise intracellular cAMP, upregulate MITF, and increase tyrosinase-mediated eumelanin synthesis in epidermal melanocyte models