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Both of these growth factors have a similar structure to insulin

This combination data is largely preclinical and short-term and has not been validated in large human trials

Goldstein, S., Naglieri, J.A., Princiotta, D., & Otero, T.M

GSH exerts its action as skin whitening agent at various levels of melanogenesis which include the following: [1],[3] Interference with cellular transport of tyrosinase Direct inactivation of the enzyme tyrosinase by binding with the copper-containing active site of the enzyme Mediating the switch mechanism from eumelanin to phaeomelanin production as GSH is the major physiologic reservoir of cysteine and increase in cysteine levels results in switching of eumelanogenesis to pheomelanogenesis [Figure - 1] Quenching of free radicals and peroxides that contribute to tyrosinase activation and melanin formation Modulation of depigmenting abilities of melanocytotoxic agents