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Discussion In this paper, we develop the first mathematical model of the GSH antioxidant system in the outer retina, capturing the most essential components for ROS creation, GSH production, oxidation in neutralizing ROS, and reduction as well as the diversion of glucose into the PPP to synthesize NADPH

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The simplest way to picture it: GLP-1 tells your gut to slow down, while amylin tells your brain you are full - through a different channel

16,19,20 This spatial arrangement demands relay mechanisms capable of bridging physical discontinuities