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this form of cell death is carried out primarily through the KEAP1/PGAM5/AIFM1 signalling pathway, thereby protecting the organism from ROS-induced damage and inflammation [105]
GLOBAL GLUTATHIONE MARKET SIZE, BY COATED TABLETS, BY REGION, 2018-2032 (USD MILLION) TABLE 164
In CIPN in vivo models induced by cisplatin, postmitotic sensory neurons in the dorsal root ganglion (DRG) are particularly sensitive to cisplatin injury, and axonal damage induced by cisplatin involves multiple events, including ROS generation, suggesting that antioxidants may help reduce the neurotoxicity of cisplatin [124, 125]
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