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Abstract Background Biological differences between women and men lead to variations in the prevalence and progression of many diseases, influencing diagnosis, management, and treatment outcomes

Thus, it can be hypothesized that the critical importance of Ca 2+ signaling in eryptosis is linked to the expulsion of the nucleus and the organelles (primarily mitochondria) in precursors of erythrocytes during erythropoiesis

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It supports ovarian function and may indirectly reduce oxidative stress via hormonal homeostasis

In a similar way, acrolein appears to stimulate oxidative stress damage, producing high levels of ceramide, which is accountable for the incrementation of cytosolic Ca 2+ concentration and, consequently, the eryptosis levels [254]