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While these results come primarily from the Khavinson research group in Russia and have not been independently replicated, they represent the most extensive human data available on pineal peptide supplementation

doi: 10.1021/acsami.4c12532 12 WangXLuoCZhangD

They showed that doses above 400 mg/kg caused an almost complete exhaustion of GSH levels in the liver and a sharp rise in the amount of covalent binding (Figure6B)

Oral glucose tolerance tests performed in clinical trials showed no significant changes in glucose handling, and fasting insulin levels remained stable throughout treatment periods

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