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[ 1 ] Doing so would allow researchers to have a more stable and standardized compound that was associated with some of the biological effects from the natural pineal extract

Elevated plasma vitamin B12 levels as a marker for cancer: A population-based cohort study

While biotin deficiency is relatively uncommon, individuals with certain metabolic conditions, those taking long-term medications such as anticonvulsants, or patients with poor nutritional absorption may benefit from intramuscular administration

In other words, if you're looking to achieve the potential health benefits associated with higher ALA and R-ALA intake, such as improved antioxidant protection or enhanced glucose metabolism, taking alpha lipoic acid supplements (or R-ALA) is often recommended