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The long-term goal isn't just to make the lab results look better, to lower the UACR or keep the eGFR from declining, so much as it is to save lives, hearts, and kidneys. Taking medications off-label is not a simple decision to make
To demonstrate specificity of the effect, we sought to rescue the decreased mEPSC frequency by pretreating with pyroglutamate (PGA), the precursor of glutamate that is synthesized downstream of GGT, which is blocked by acivicin (Fig
References Langer HT, Gilmore NK, Hayden CMT, et al
In fact, its the added acetyl group that allows it to cross the blood-brain barrier, which standard L-carnitine doesnt do as easily
A prospective RCT with dual metabolic and psychiatric endpoints, enrolling patients with active depression or anxiety plus diabetes or obesity, stratified by SUD comorbidity and baseline anhedonia severity that trial is buildable, and the recruitment population is not hypothetical
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