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Kumar, Berberine shows data for improved glucose metabolism, so its something that could be considered more of a natural Metformin, but [it does have] he level of clinical efficacy of a GLP-1. Metformin is another prescription medication sometimes prescribed for weight loss

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2012 Dec;1826(2):443-57

Some researchers also suggest it may interact with neurons via the Mitogen-Activated Protein Kinase (MAPK) pathway, which regulates intercellular signaling [15]

Comment A minimal to moderate peribiliary inflammatory cell infiltration consisting primarily of mononuclear cells can occur commonly in the livers of rats and mice and increases in incidence with animal age