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Reminder: Microdosing remains experimental with no clinical trial validation
Melanotan/ MT2 peptides activate melanocortin receptors, especially MC1 receptors, on melanocytes (melanin or pigment producing cells)
The key characteristic of this superfamily is a pore domain comprised of two transmembrane segments connected by a re-entrant pore loop, which enters and exits the membrane on the same side and typically serves as a selectivity filter (Wollmuth and Sobolevsky, 2004
For those whose weight loss plateaus, that seemingly small milligram gap can be fairly meaningful
If 8mg of retatrutide gives you 22% weight loss with manageable side effects, is the extra 6% from 12mg worth the increased nausea and dysesthesia risk
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