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This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice
This product is intended for research use only and is not for human consumption
Niacinamide (Vitamin B3): A high-purity skin-perfecting agent that refines skin texture and strengthens the thin moisture barrier, effectively improving light reflection for a refreshed effect
10.1046/j.1365-2133.2003.05417.x Br J Dermatol
When cells are exposed to oxidative and/or electrophilic stress, KEAP1 thiol residues are directly modified, which inactivates the ubiquitin E3 ligase activity of KEAP1-CUL3 complex, leading to stabilization of NRF2
