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(1) The downregulation of glycolytic/gluconeogenic nodes (PycAB, Mqo1, and MaeB) coupled with upregulation of oxaloacetate decarboxylase (Oad), which establish oxaloacetate as the predominant entry point for TCA cycle influx

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[31] [32] [33] Similarly, in humans, renal proximal tubular cells contain high concentrations of alpha GST, while distal tubular cells contain pi GST

For instance, in Bifidobacterium animalis subsp

While glutathione synthesis is controlled by multiple factors, GCL is the main determinant, because the rate-limiting step is the cellular level of the amino acid cysteine