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Important safety considerations include a boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), and pregnancy avoidance (with a 2-month washout period before conception)

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PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice

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