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If you're feeling fatigued, have trouble concentrating, or suffer from mood swings, it could be a sign of a B12 deficiency

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Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)

using a higher volume produces a more dilute solution, which may be easier to measure accurately

[PMID: 10944712] PubMed record related to this compound for laboratory literature review