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A well-designed glutathione conjugation strategy considers substrate electrophilicity, the role of the cysteine thiol versus terminal amino or carboxyl groups, protection and deprotection needs, solvent and pH compatibility, oxidation risk, and the downstream analytical question the customer actually needs to answer

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Supporting the view that APAP is neurotoxic, a 2010 study of adult rats demonstrated that APAP induces the death of cortical neurons at concentrations lower than those required to induce acute liver failure [13].A recent summary statement by Bauer et al

Cell 20 , 0 (2009)