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A total of 40 participants were selected and randomized into two sequences in a double-blind, placebo-controlled crossover design, with a one-week washout period between treatments to eliminate carryover effects

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Indian dermatologists widely recommend the oral route as the first-line option

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Four doses of 100 mg and 200 mg of DHB produced significantly greater concentrations of plasma berberine across the 2-hour measurement window than a 500-mg dose of berberine or placebo