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Gradual dose titration, structured nutritional guidance, symptom monitoring, and early imaging when indicated are effective strategies to reduce complications while maintaining metabolic benefit

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Common guidelines include: Initial dose: Often 0.5 mg/kg/day for the first month Typical dose: 0.51.0 mg/kg/day based on response and tolerance Cumulative dose: 120150 mg/kg over a complete course Administration: Take with food to increase absorption For example, an 80 kg person may be prescribed 20 mg twice daily to approach a 1 mg/kg/day regimen over 45 months