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Mice administered with Melanotan II are found to reject fatty foods they would otherwise enjoy
An emerging and highly promising strategy involves developing multi-target agonists that also engage the glucagon-like insulinotropic polypeptide receptor (GIPR) and/or the glucagon receptor (GCGR) [14, 15]
To investigate further, this study presented the BPC-157 peptide in amphetamine (dopamine agonist) murine models
The main difference between the mechanisms of action of the two drugs is that liraglutide only acts on the GLP-1 receptor, while tirzepatide is a co-agonist of GIPR next to the GLP-1R with a greater affinity to the GIPR [39]
In conclusion, while GLP-1RAs and GLP-1/GIP dual agonists offer significant clinical advantages, ongoing research and vigilant monitoring of their adverse effects and safety are essential for optimizing their therapeutic application
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