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Direct involvement of hydrogen peroxide in the activation of NF-B has been discussed ( 102 inhibited the TNF induced activation of NF-B pathway dose-dependently with an EC 50 of 60.8 M ( Figure 6 )
doi: 10.1210/mend.6.10.1333056 55 MckeeK
Targeting metabolic- and plasticity- related systems by augmenting insulin and IGF-1 signaling may be considered a therapeutic strategy for reducing AUD-related cognitive deficits
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