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[12] Adverse effects [edit] Preclinical, phase I, and phase II clinical trials indicated that tirzepatide exhibits adverse effects similar to those of other established GLP-1 receptor agonists, such as dulaglutide (sold as Trulicity) and semaglutide (sold as Wegovy, Ozempic, and Rybelsus)

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These consisted of five clinical trials, four real-world observational studies and the completed trial (SURPASS-CVOT) was included separately to serve as a contextual cardiovascular outcomes study

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