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Studies reviewed by Hector and Burton involving 91 patients with hypovitaminosis B12 who exhibited neuropsychiatric symptoms found that clinical improvement was achieved in many individuals through vitamin B12 replacement therapy (26)

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Changes in brain GSH levels after (in)GSH administration The duration of post-dose measurements was driven by participant comfort and scheduled time in scanner, up to the duration of time approved by the institutional review board

As we age, our glutathione levels naturally decline, leading many to explore supplementation as a strategy to combat the signs of aging

Future studies should standardize methodological approaches across populations and increase sample sizes