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TRPV1 modulation also indirectly influences melanogenesis and the production of protective pigments like melanin, which can shield against UV-induced oxidative damage 160

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While nicotine itself is not considered to be carcinogenic, each cigarette contains a mixture of carcinogens, including a small dose of polycyclic aromatic hydrocarbons (PAHs) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) among other lung carcinogens, tumor promoters, and co-carcinogens

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