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doi:10.1200/JCO.2015.61.1095 Anderson C, Harrigan M, George SM, et al
His early excavations were traditional affairs, but led him to a realisation that empirical research required clearly defined questions, and methods that matched the scale of the problem
In the landmark 72-week SURMOUNT-1 trial, participants on the 15 mg dose recorded a mean body-weight reduction of 20.9%, versus 3.1% on placebo[1]. 57% of that group lost a fifth or more of their body weight, and 91% lost at least 5%[1]
Animal models suggest that while -cell glucokinase is crucial for liraglutide-induced insulin secretion, liraglutide may still enhance glycemic control, reduce steatosis, and prevent -cell death through mechanisms independent of glucokinase 80
Nausea, bloating, and fatigue are common during the first few weeks of treatment
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