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Randomised withdrawal trials across this class consistently show substantial regain after discontinuation, with a 2026 review reporting that roughly two-thirds of lost weight is typically regained within a year of stopping, alongside reversal of some cardiometabolic improvements

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[13] Because tretinoin potentiates ultraviolet-induced erythema, patients undergoing phototherapy or receiving photosensitizing drugs should avoid the cream to prevent exaggerated inflammatory reactions

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[Abstract]2021 Jun 18;4(8):e202000906