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In retatrutide trials specifically, starting at 4 mg instead of 2 mg nearly doubled early GI symptom rates

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Doi:10.1210/jc.2006-1702 The information in this article is intended for educational use only and shouldn't be considered medical advice

NNMT is a metabolic enzyme that regulates cellular energy and methylation potential by preventing NAM (Nicotinamide) from participating in the NAD+ Salvage Pathway and converting back into NAD+

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