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Pathways enriched for DEGs selected from Gipr fl/fl vehicle versus Gipr Syn/ vehicle, as well as Gipr fl/fl vehicle versus Gipr fl/fl mGIPR-Ab/P1 comparisons, demonstrated that reduction of CNS GIPR function through either pharmacological or genetic intervention led to downregulation within adipose tissue of key canonical genes within these pathways (Fig

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The findings were compelling, tirzepatide not only achieved greater reductions in HbA1c but also delivered significant body weight loss, all while showing a lower incidence of hypoglycemia at the 52-week mark