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220 This is further supported by studies in caloric restriction, a type of nutrient restriction that has the effect of lowering both insulin and IGF-1 signaling and increasing longevity

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Tomassini, V., Pozzilli, C., Onesti, E., Pasqualetti, P., Marinelli, F., Pisani, A., and Fieschi, C

On the other hand, GLP-1-based therapies can alter gut microbiota composition and diversity, potentially exerting anti-inflammatory effects that influence host metabolism and overall health

Liquid iron formulations or lower doses may be better tolerated