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Alcohol disrupts this protective communication between macrophages and hepatocytes, inhibiting ISG induction and increasing HBV replication, which weakens innate antiviral immunity ( Recent single-cell RNA sequencing (scRNA-seq) studies have further clarified macrophage heterogeneity and functional states in the context of HBV infection and alcohol exposure

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Researchers have extensively studied NNMT due to observations linking elevated NNMT activity with changes in adipose tissue biology, metabolic efficiency, and energy regulation

Schairer DO, Chouake JS, Kutner AJ, Makdisi J, Nosanchuk JD, Friedman AJ