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A 2024 pharmacovigilance analysis of a global drug safety database found that GLP-1 receptor agonists, including semaglutide, had reporting-odds ratios suggesting associations with depression, anxiety, and, in rare cases, suicidal ideation
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By October 2024, it was estimated that millions of patients were taking compounded GLP-1 medications
By inhibiting the Gas proteins and facilitating receptor trafficking through internalization and recycling, these beta arrestins are essential for GIP receptor desensitization
(2025) 169:S1220
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