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Journal of Medicinal Chemistry, 2015, 58(18):7370.DOI:10.1021/acs.jmedchem.5b00726
Unlike topical sunscreens that physically block or absorb UV radiation before it penetrates the skin, astaxanthin's primary mechanism involves neutralizing the reactive oxygen species generated by UV exposure after it occurs
At clinical doses under supervision, the most common side effects are mild nausea in the first week (typically resolves by day 7 to 10), injection site reactions (redness, minor swelling, localized soreness lasting 24 hours), and occasional transient fatigue or mild headache in the first few days
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