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This could be a subgroup that particularly benefits from these new anti-obesity drugs, he hypothesizes

First, although all included studies were high-quality large-scale RCTs, their small number restricted our ability to explain sources of heterogeneity through subgroup analyses

3.3 Analyses of Additional Cardiovascular Effects Applying cardiovascular effects to the proportion of patients in PIONEER 2 and PIONEER 3 who met the PIONEER 6 inclusion criteria (17% of the total patients in PIONEER 2 and 21% in PIONEER 3 [15, 16]) had a moderate impact on cost effectiveness

By contrast, GLP-1 medications are still being understood in this context

The idea behind this kitchen-sink formulation is to streamline your health regimen