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A study in rats ( Yet another aspect to consider is the recurring theme of precision medicine
Chung, J.Y., J.H
In our model, depletion of Hypoxia-Inducible Factor 1 alpha (HIF-1) impaired the effects of Exendin-4 on glucose metabolism, while pharmacological inhibition of Phosphoinositide 3-kinase (PI3K) or mTOR completely abolished such effects
GLP-1 receptor activation mimics satiety signals sent to the brain, specifically the hypothalamus, which regulates appetite and food intake
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