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The modality is novel enough that if Phase 1 PK/PD confirms durable receptor coverage, it will open an entirely new format vector for incretin drug development

ApoAI (Apolipoprotein AI): Associated with: High-Density Lipoproteins (HDL) Function: ApoAI is the major protein component of HDL and plays a central role in HDL metabolism

LC-MS offers the sensitivity required to detect these very low impurity levels

India Patent expires: March 2026 Adult population: 947 million Proportion of adults living with obesity a : 8% Proportion of adults living with diabetes b : 11% China Patent expires: March 2026 Adult population: 1.07 billion Proportion of adults living with obesity a : 9% Proportion of adults living with diabetes b : 12% Brazil Patent expires: March 2026 Adult population: 155 million Proportion of adults living with obesity a : 31% Proportion of adults living with diabetes b : 11% Trkiye Patent expires: 2026 Adult population: 59.0 million Proportion of adults living with obesity a : 36% Proportion of adults living with diabetes b : 16% Canada Patent expires: 2026 Adult population: 29.1 million Proportion of adults living with obesity a : 27% Proportion of adults living with diabetes b : 10% World Population: 8.23 billion More than 1 billion people in the world have a body mass index (BMI) 30 kg/m 2

In many ways, Wegovy is simply a higher-dose version of Ozempic, as they both contain the same active ingredient