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A combination can be scientifically interesting and still remain unapproved for human use
where 0.4368 is the average value of E 2( t ) during the cycle (calculated from Panel A of Figure 2)
While estrogens play a leading role in womens skin, other hormones such as progesterone, the androgens, androstenedione, and testosterone also have an influence on dermal health and well-being with aging, which have been reviewed in detail elsewhere [10]
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